Development and validation of UV Spectrophotometric method for simultaneous estimation of Tizanidine hydrochloride and Mefenamic acid in their combined tablet dosage form. For this dual wavelength method, where 246 nm and 261 nm were selected as ?1 and ?2 for the determination of Tizanidine hydrochloride and 230 nm and 245 nm were selected as ?1 and ?2 for the determination of of Mefenamic acid. Tizanidine hydrochloride showed linearity in the range of 0.5-1.5�µg/mL and Mefenamic acid showed linearity in the range of 6-9 �µg/mL in all the methods. Method was validated statistically and recovery studies were carried out. This method was found to be accurate, precise and reproducible. This method was applied to the assay of the drugs in marketed formulation, which were found in the range of 98.0% to 100.0% of the labelled value for both Tizanidine hydrochloride and Mefenamic acid. New, simple, accurate and precise UV spectrophotometric method have been developed and validated for the simultaneous determination of Tizanidine hydrochloride (TZN) and Mefenamic acid (MEF) in their combined dosage form.
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